Dr Gopi Rangan
Westmead Kidney Regeneration Laboratory
Gopi Rangan is Senior Lecturer (Conjoint) in the Faculty of Medicine at the University of Sydney and Senior Staff Specialist in Nephrology at Westmead and Blacktown Hospitals. He graduated in Medicine from the University of New South Wales (Sydney) and undertook postgraduate training in Nephrology in Canberra, Perth and Sydney.
He became a Fellow of the Royal Australasian College of Physicians (RACP) and subsequently awarded a PhD from the University of Sydney for research into the role of nuclear factor-B in chronic glomerular disease. He undertook postdoctoral training investigating the role complement proteins in chronic kidney disease with the ‘Glomerular Diseases Group’ at the Division of Nephrology, University of Washington, Seattle, USA.
He has been a Staff Specialist in Nephrology at Fremantle Hospital, Clinical Senior Lecturer in Pharmacology at the University of Western of Australia (2001-03) and a recipient of the Australian Kidney Foundation (Kidney Health Australia) Biomedical Scholarship; the Don and Lorraine Jacquot Fellowship from the RACP; the Bernie Amos Fellowship from Westmead Hospital; and the Australian and New Zealand Society of Nephrology Travelling Fellowship.
He was awarded a New Investigator Grant from the NHMRC and established the Kidney Regeneration Group at the Centre for Transplant and Renal Research in 2003.
Research Interests
CKD affects more than 2 million Australians as well as countless others throughout the world. It is a major health problem because of its inevitable progression to end-stage kidney failure, where chronic dialysis and kidney transplantation are required for survival. The focus of the laboratory’s research has been the role of cellular growth and regeneration in chronic kidney diseases.
The aim is to develop novel biological- and nano-based drug therapies to regenerate the chronically injured kidney and prevent end-stage renal failure. There are three translational programs in the laboratory:
- The modulation of the cell cycle in tubular epithelial cells to regress cyst formation and growth in polycystic kidney disease;
- The control of autoimmune-mediated immune cell expansion and renal cell proliferation in glomerulonephritis (focal segmental glomerulosclerosis and crescentic glomerulonephritis);
- The development of generic molecular and cell regenerative approaches to reduce proteinuria, fibrosis and tissue atrophy, applicable to a broad range of chronic kidney diseases.
Publications
- Rangan GK, Pippin J, Couser WGC. C5b-9 regulates peritubular myofibroblast accumulation in proteinuric rats. Kidney Int 66:1838-48, 2004.
- Rangan GK, Pippin J, Coombes J, Couser WGC. C5b-9 does not mediate chronic tubulointerstitial damage in the absence of proteinuria Kidney Int 67:492-503, 2005.
- Coombes JD, Mreich E, Liddle C, Rangan GK. Rapamycin inhibits tubular proliferation and worsens renal function in protein-overload nephropathy. Kidney Int 68: 2599-2607, 2005.
- Rangan GK. Sirolimus-Associated Proteinuria and Renal Dysfunction: Clinical Significance and Mechanisms. Drug Safety. 29: 1153-1161, 2006.
- Mreich E, Coombes JD, Rangan GK. Sirolimus does not reduce receptor-mediated endocytosis of albumin in proximal tubule cells. Transplantation. 83:105-7, 2007.
- Phillips J, Hopwood D, Loxley R, Ghatora K, Coombes JD, Tam YS, Harrison JL, McKitrick DJ, Holobotvskyy, Arnolda LF, Rangan GK. Temporal relationship between renal cyst development, hypertension and cardiac hypertrophy in autosomal recessive polycystic kidney disease. Kidney Blood Press Res 19:129-144, 2007.
- Rangan GK, Coombes JD. Renoprotective effects of sirolimus in non-immune initiated focal segmental Glomerulosclerosis Nephrol Dial Transplant (in press), 2007.
- Rangan GK, Tesch GH. Quantification of renal pathology by image analysis. Nephrology (in press), 2007.
Contact details
T +61 2 9845 6962
F +61 2
9633 9351
E g.rangan@wmi.usyd.edu.au
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