 Clinical Associate Professor Philip O'Connell
Director, Transplantation and CTRR
Philip O'Connell is a Clinical Associate Professor in Medicine. He is Director of the Centre for Transplant and Renal Research and Director of Transplant Medicine and the Clinical Islet Transplant Program at Westmead Hospital.
He gained his medical degree at the University of NSW and undertook a PhD at the University of Melbourne with Professor Tony d'Apice in the department of Professor Kincaid-Smith.
He then went on to do Post-doctoral research in transplantation immunology with Professor Terry Strom, Harvard Medical School before returning to Westmead Hospital as a nephrologist.
Research Interests
His main research interest is in islet transplantation and he is director of the Australian Clinical Islet Transplant Consortium.
His laboratory research is focused primarily on the immunobiology of islet xenograft rejection and developing islet xenografts as a clinical therapy. He is past-director of a joint NHMRC/JDRF program grant that is devoted to the development of pig islets as treatment for Type 1 diabetes.
His other focus is the study of kidney graft outcome using new research technologies such as gene-chip microarray technology. This research is funded by the NIH.
He has long-standing collaborations with researchers at, Mount Sinai School of Medicine New York, Harvard Medical School, Walter and Eliza Hall Institute, St Vincent's Hospital Melbourne, The Garvan Institute, Adelaide University and The Children's Hospital at Westmead.
Publications
- Yi S, Hawthorne W, Lehnert AM, Ha H, Wong JKW, van Rooijen N, Kelly Davey, Patel AT, Walters SN, Chandra A, O’Connell PJ. T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts. J Immunol. 2003, 170; 2750-2758.
- Nankivell BJ, Borrows RJ, Fung CL-S, O’Connell PJ, Allen RDM, Chapman JR. The natural history of chronic allograft nephropathy. N Engl. J. Med. 2003, 349; 2326-33.
- O’Connell PJ. Thrombotic microangiopathy: the next big hurdle for xenotransplantation. [editorial] J. Am. Soc. Nephrol . 2005, 16: 2529-30.
- O’Connell PJ, Hawthorne WJ, Holmes-Walker DJ, Nankivell BJ, Gunton JE, Patel AT, Walters SN, Pleass HCC, Allen RDM, Chapman JR. Clinical islet transplantation in type 1 diabetes mellitus: results of Australia’s first trial. Med. J. Aust. 2006, 184: 221-25.
- Yi S, Wang Y, Chandra AP, O’Hara JM, Wu J, Ouyang L, Burgess JS, Hawthorne WJ, Wu H, Chadban SJ, O’Connell. Requirement of MyD88 for macrophage mediated islet xenograft rejection after adoptive transfer. Transplantation 2007, 83; 615-23.
- Nankivell BJ, Wavamunno MD, Borrows RJ, Vitalone M, Fung C L-S, Allen RDM, Chapman JR, O’Connell PJ. Mycophenolate mofetil is associated with altered expression of chronic renal transplant histology. Am J. Transplant. 2007, 7; 366-76.
Contact Details
T +61 2 9845 6962
F +61 2 9633 9351
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