 Dr Graham Jones
Molecular Genetics of Asthma and Atopic Dermatitis
Dr Graham Jones holds a BSc (Hons) University of Sydney, 1986 and PhD University of Sydney, 1991.
Post-doctoral experience at the University of Basel, Switzerland (1992-1998). Research during this time was focussed on the activation of cell surface receptor tyrosine kinases by the extracellular matrix and the regulation of gene transcription by these receptors. This theme was continued during his time at the University Hospital (1998-2001), Basel, and also included the study of human genetics in disease.
Research Interests
Since returning to Australia in 2001, Graham's research program has continued to integrate human genetics with cellular and molecular biology, focussing on the immune system.
Genetic association studies of children with severe atopic dermatitis have identified several genes encoding cell surface receptors and nuclear transcription factors.
Work is now well advanced on understanding how heritable polymorphisms in these genes lead to changes in gene or protein function.
Publications
2006
- Berglund, L, Jones, G, Murali, R, Fulcher, D. TACI mutation with invasive polyclonal CD8+ T-cell lymphoproliferation in a patient with common variable immunodeficiency. The Journal of allergy and clinical immunology. 2006; 117:870-7 [Abstract]
- Jones, G, Wu, S, Jang, N, Fulcher, D, Hogan, P, Stewart, G. Polymorphisms within the CTLA4 gene are associated with infant atopic dermatitis. The British journal of dermatology. 2006; 154:467-71 [Abstract]
- Page, N, Jones, G, Stewart, G. Genetic Association Studies between the T Cell Immunoglobulin Mucin (TIM) Gene Locus and Childhood Atopic Dermatitis. International archives of allergy and immunology. 2006; 141:331-6 [Abstract]
2005
- Jang, N, Stewart, G, Jones, G. Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis. Genes and immunity. 2005; 6:262-4 [Abstract]
2004
- Jones, G, Stewart, G. Nuclear import of N-terminal FAK by activation of the FcepsilonRI receptor in RBL-2H3 cells. Biochemical and biophysical research communications. 2004; 314:39-45 [Abstract]
2001
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Jones G., Machado J., Tolnay, M, Merlo A. (2001) PTEN-independent induction of caspase-mediated cell death and reduced invasion by the focal adhesion targeting domain (FAT) in human astrocytic brain tumors which highly express focal adhesion kinase (FAK) Cancer Research 61:5688-5691
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Jones G., Machado J., Merlo A. (2001) Loss of FAK inhibits EGFR-dependent migration and induces aggregation of N-terminal FAK in the nuclei of apoptotic glioblastoma cells. Cancer Research 61:4978-4981
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Labuhn M., Jones G., Speel E. J. M., Maier D., Zweifel C., Gratzl O., Van Meir E. G., Hegi M., Merlo A. (2001) Quantitative real-time PCR does not show selective targeting of p14ARF but concomitant inactivation of both p16INK4A and p14ARF in 105 human primary gliomas. Oncogene. 20:1103-9.
1999
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Maier D., Jones G., Li X., Schonthal A., Gratzl O., Van Meir E. G., Merlo A. (1999) The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells. Cancer Research 59, 5479-5482
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Jones G., Moore C., Hashemolhosseini S., Brenner H. R. (1999) Constitutively active MuSK is clustered in the absence of agrin and induces ectopic post-synaptic like membranes in skeletal muscle fibres. J. Neurosci. 19, 3376-3383.
Contact Details
T +61 2 9845 8826
F +61 2 9891 3889
E graham_jones@wmi.usyd.edu.au
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