 Dr Julianne T Djordjevic
CIDM - Fungal Pathogenesis Research Group
Julianne Djordjevic completed her PhD at the Department of Biochemistry, University of Queensland in 1995, where she investigated mechanisms of development of the disease hypercholesterolemia and contributed to the determination of the structure of cholesterol-binding modules of the low density lipoprotein (LDL) receptor.
She has held post-doctoral positions within the Departments of Rheumatology and Immunology at the Westmead Millennium Institute (WMI), investigating the mechanisms of T cell function and the pathogenesis of HIV infection. In January 2003, she was recruited to the Centre for Infectious Diseases and Microbiology (CIDM), at the WMI, to establish an internationally competitive laboratory in molecular fungal pathogenic studies using Cryptococcus neoformans as the model pathogen.
Research Interests
In March 2005, Julianne was appointed to a tenured position as head of the CIDM Fungal Pathogenesis Group and as a "Research Fellow" with the University of Sydney. Specifically, she is working on determining the mechanism and regulation of secretion of the fungal virulence determinant, phospholipase B1 (PLB1), from Cryptococcus neoformans and in particular, on defining the role of glycosylphosphatidylinositol (GPI) membrane anchors, specialized membrane subsets, termed rafts and glucanases in this process. Through the use of targeted gene disruption technology, she is also interested in discovering new determinants of fungal virulence that could serve as potential targets for the development of new classes of antifungal drugs.
Publications
- 2008 - 2007 - 2006 - 2005 - 2004 - 2003 - 2002 -
2008
-
Chayakulkeeree, M, Sorrell, TC, Siafakas, AR, Wilson, CF, Pantarat, N, Gerik, KJ, Boadle, R and Djordjevic, JT. (2008) Role and Mechanism of Phosphatidyl-inositol Specific Phospholipase C in Survival and Virulence of Cryptococcus neoformans. Accepted 22th March Molecular Microbiology. [Abstract]
2007
- Wright, LC, Santangelo, RM, Ganendren, R, Payne, J, Djordjevic, JT, and Sorrell TC. (2007) Cryptococcal lipid metabolism: Phospholipase B1 is implicated in transcellular metabolism of macrophage-derived lipids. Eukaryotic Cell, Vol 6(1) 37-47 [Abstract]
- Jones P, Turner KM, Djordjevic JT, Sorrell TC, Wright LC, George AM. Role of Conserved Active Site Residues in Catalysis by Phospholipase B1 from Cryptococcus neoformans (2007) Biochemistry 46, 10024-10032 [Abstract]
- Siafakas, AR. Sorrell TC, Wright LC, Wilson CF, Larsen, M, Boadle, R, Williamson, PR and JT. Djordjevic. Cell Wall-Linked Cryptococcal Phospholipase B1 is a Source of Secreted Enzyme and a Determinant of Cell Wall Integrity. J. Biol. Chem. Dec 28; 282(52), 37508-37514. Epub: Oct 18 2007. [Abstract]
2006
-
Siafakas, AR, Sorrell, TC Wright LC and Djordjevic, JT (2006) Lipid rafts in Cryptococcus neoformans concentrate the virulence determinants phospholipase B1 and Cu/Zn superoxide dismutase. Eukaryotic Cell. 5(3):488-498. [Abstract]
-
Turner, KT, Wright, LC, Sorrell TC, and Djordjevic, JT (2006) N-linked glycosylation sites selectively affect secretion of cryptococcal PLB1, irrespective of glycosylphosphatidylinositol anchoring. Biochimica et Biophysica Acta 1760, 1569-1579. [Abstract]
2005
-
Djordjevic, JT, Del Poeta, M , Sorrell, TC , Turner, KM. and Wright, LC. Secretion of cryptococcal phospholipase B1 (PLB1) is regulated by a glycosylphosphatidylinositol (GPI) anchor (2005) Biochem. J. 389(3):803-12. [Abstract]
2004
- Santangelo, R, Zoellner, H, Sorrell, TC, Wilson, C, Donald, C, Djordjevic, JT, Shounan, Y, & Wright, LC. (2004) The role of extracellular phospholipases and mononuclear phagocytes in the dissemination of cryptococcosis in a murine model. Infect. Immun. 72, 2229-2239. [Abstract]
- Djordjevic, JT, Schibeci, SD, Stewart, GJ & Williamson, P. (2004). HIV-1 Nef increases association of T-cell receptor signaling molecules with rafts and promotes T-cell raft fusion. AIDS Res. & human retroviruses 20:547-55. [Abstract]
2003
- Wright, LC, Djordjevic, JT, Schibeci, SD, Muljadi, N, Williamson, P, & Lynch, GW. (2003). Lipid rafts form part of the 1H NMR-visible lipid in cells. European J. Biochem. 270(9):2091-100
2002
- Djordjevic, JT, Wang, MX, Bender, V, & Manolios, N. (2002). T cell antigen receptor (TCR) transmembrane peptides colocalize with TCR, not lipid rafts, in surface membranes. Cellular Immunology 215: 12-19 [Abstract]
- Djordjevic, JT, Wang, MX, Lee, L, Schibeci, SD, Williamson, P & Manolios, N. (2002). T cell antigen receptor (TCR) peptides inhibit signal transduction within membrane lipid bilayers. Clinical Immunology, 105(2):199-207
Contact Details
T +61 2 9845 7367
F + 61 2 9891 5317
E julie_djordjevic@wmi.usyd.edu.au
|
