Dr Anna deFazio

Gyneacological Oncology Research Group

• Research Interests
• Publications
• Contact Details

Anna deFazio is Senior Clinical Lecturer, Department of Obstetrics and Gynaecology, University of Sydney and the Head of the Gyneacological Oncology Research Group, Westmead Institute for Cancer Research at Westmead Hospital.

She graduated from the University of New South Wales in 1981(BSc, Hons) and went on to complete a PhD in the Department of Cancer Medicine / Ludwig Institute for Cancer Research, University of Sydney in 1987.

She embarked on postdoctoral studies at the Garvan Institute of Medical Research in Sydney (1988-1995) and moved to the Department of Gynaecological Oncology at Westmead Hospital in 1995. Dr deFazio was appointed a Senior Clinical Lecturer of the University of Sydney in 1999.

Research Interests

Dr deFazio has long standing commitment to translational research with an emphasis on gynaecological malignancies. Her research program is focussed on improving treatment outcome, particularly for patients with ovarian cancer, and on identifying factors that modify risk of developing cancer.

She works with a small team of postdoctoral researchers, postgraduate students and research staff and has active collaborations with other local and national research groups. The group is supported by national and international peer-reviewed grants.

Dr deFazio is on the management committee of the Australian Ovarian Cancer Study (AOCS), a national molecular epidemiology study on ovarian cancer and is the head of the AOCS Clinical Follow-up Core. She is also a chief investigator for the Australasian Biospecimens Network (ABN-Oncology).

Publications

- 2007 - 2006 - 2005 - 2004 - 2003 - 2002 - 2001 - 2000 -

2007

• Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O’Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew Y-E, deFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan M-H, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR. (2007). Patterns of somatic mutation in human cancer genomes. Nature. 446:153-158.
• Arnett-Mansfield RL, Graham J, Hanson A, Mote PA, Gompel A, Scurr L, Gava N, deFazio A,Clarke CL. (2007). Focal subnuclear distribution of progesterone is ligand-dependent and associated with transcriptional activity. Mol Endocrinol, 21:14-29.
• Catchpoole D, deFazio A, Devereux L, Fleming M, Hof M, Schmidt C, Thorne H, Zeps N. (2007). The importance of biorepository networks: the Australasian Biospecimen Network - Oncology. Aust J Med Sci, 28: 16-20.

2006

• Mote PA, Arnett-Mansfield RL, Gava N, deFazio A, Mulac-Jericevic B, Conneely O, Clarke CL. (2006). Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Endocrinology. 147:5503-5512  [Abstract]

• Guminski, AD, Balleine, RL, Chiew, Y-E, Webster, LR, Tapner, M, Farrell, G, Harnett, PR, and deFazio, A. (2006).. MRP2 (ABCC2) expression and cisplatin sensitivity in hepatocytes and human ovarian carcinoma. Gynecol Oncol. 100: 239-246.

2005

• Aghmesheh M, Edwards L, Clarke CL, Byth K, Katzenellenbogen BS, Russell PJ, Friedlander M, Tucker KM, deFazio A. (2005). Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas. Gynecol. Oncol. 97:16-25  [Abstract]

• Byrne J, Balleine RL, Schoenberg-Fejzo M, Mercieca J, Chiew Y-E, Livnat Y, St. Heaps L, Peters G, Byth K, Karlan B, Slamon D, Harnett PR, and deFazio A. (2005) Tumor Protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian carcinoma. Int J Cancer, 117:1049-1054.

2004

• Gava N, Clarke CL, Byth K, Arnett-Mansfield RL, deFazio A. (2004). Expression of progesterone receptors A and B in the mouse ovary during the estrous cycle. Endocrinology. 145:3487-3494  [Abstract]
• Balleine RL, Earls P, Webster L, Mote PA, deFazio A, Harnett P, Clarke, CL. (2004). Expression of progesterone receptor A and B isoforms in low-grade endometrial stromal sarcoma. Int J Gyn Pathol . 23:138-144  [Abstract]
• Arnett-Mansfield RL, deFazio A, Mote PA, Clarke CL. (2004). Subnuclear distribution of progesterone receptors A and B in normal and malignant endometrium. J Clin Endocrinol Metab . 89:1429-1442  [Abstract]

2002

• Kennedy C, Byth K, Clarke CL and deFazio A. (2002). Cell proliferation in the normal mouse mammary gland and inhibition by phenylbutyrate. Mol Cancer Ther . 1: 1025-1033.

• Guminski AD, Harnett PR and deFazio A. (2002). Scientists and clinicians test their metal - back to the future with platinum compounds. Lancet Oncol. 3: 312-318 .

2001

• Arnett-Mansfield RL, deFazio A, Wain GV, Jaworski R, Byth K, Mote PA and Clarke CL (2001). Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium. Cancer Res. 61: 4576-4582.

• Guminski A.D, Harnett PR and deFazio A. (2001). Carboplatin and paclitaxel interact antagonistically in a megakaryoblast cell line - a potential mechanism for paclitaxel-mediated sparing of carboplatin-induced thrombocytopenia. Cancer Chemother Pharmacol . 48: 229-234.

2000

• Davis T, Kennedy C, Chiew Y-E, Clarke CL, deFazio A.(2000). Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clin Cancer Res., 6: 4334-4434.

Contact Details

T +61 2 9845 7376

F +61 2 9845 7793

E anna_defazio@wmi.usyd.edu.au