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Associate Professor Christine ClarkeAssociate Professor Christine Clarke

Breast Cancer Research Group

Christine Clarke is Associate Professor, Department of Medicine, University of Sydney and a National Health and Medical Research Council (NHMRC) Principal Research Fellow, based at the Westmead Millennium Institute, Westmead Hospital. She is also heads the Translational Oncology Unit, Sydney West Area Health Service.

She graduated in Science with BSc Honours (First Class), from the University of New South Wales in 1977 and went on to complete a PhD in Biochemistry at the same university in 1982.

She embarked on postdoctoral studies overseas, spending time in France at INSERM, Paris, France (1982-1983) and in the United States (Pennsylvania State University, Hershey, Pennsylvania, 1983-1987). She returned to Australia as a Research Fellow at the Garvan Institute of Medical Research in Sydney (1987-1990), and was appointed as a NHMRC RD Wright Fellow in 1991. She moved to the University of Sydney in 1992 and was appointed as an NHMRC Research Fellow in 1993. .

 

Research Interests

 

A major goal of the Breast Cancer Research Group is to understand the the mechanisms of action of the female hormone progesterone in the normal breast and in breast cancer, with the eventual aim of understanding the role of steroid hormones in cancer development and progression. Research projects include basic studies on mechanisms of transcriptional regulation of progesterone receptor, and definition of pathways of progesterone action in models of normal human breast. The research team manitains a commitment to translation and to emphasis on findings in human tissues to guide its research directions.

 

A/Prof Clarke works with a small team of postdoctoral researchers, postgraduate students and research staff. The group is supported by state and national peer-reviewed grants.

 

A/Prof Clarke also leads the Breast Cancer Tissue Bank, a NSW-wide initiative funded by the NHMRC, the National Breast Cancer Foundation and the Cancer Institute NSW, to collect breast cancer tissues and clinical information and make these available to researchers around the country.

 

Click here for information on Westmead Institute for Cancer Research.

 

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Publications

 

- 2006 - 2005 - 2004 - 2003 - 2002 - 2001 - 2000 -

 

2006

  • Cowell, L, Graham, J, Bouton, A, Clarke, C, O'neill, G. Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene. 2006; 25:7597-607 [Abstract]
  • Mote, P, Arnett-Mansfield, R, Gava, N, de Fazio, A, Mulac-Jericevic, B, Conneely, O, Clarke, C. Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Endocrinology. 2006; 147:5503-12 [Abstract]
  • Arnett-Mansfield, R, Graham, J, Hanson, A, Mote, P, Gompel, A, Scurr, L, Gava, N, Defazio, A, Clarke, C. Focal subnuclear distribution of progesterone receptor is ligand-dependent and associated with transcriptional activity. Molecular endocrinology ( Baltimore , Md. ). 2006; 21:14 -29 [Abstract]
  • Wong, M, Balleine, R, Blair, E, McLachlan, A, Ackland, S, Garg, M, Evans, S, Farlow, D, Collins, M, Rivory, L, Hoskins, J, Mann, G, Clarke, C, Gurney, H. Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2006; 24:2448-55 [Abstract]
  • Carpenter, J, Clarke, C. Twenty-first century tissue banking: Lessons from the past are shaping the future - Breast Cancer Tissue Bank, Australia . Cell Preservation Technology. 2006; 4:219-219 [Abstract]
  • Mann, G, Thorne, H, Balleine, R, Butow, P, Clarke, C, Edkins, E, Evans, G, Fereday, S, Haan, E, Gattas, M, Giles, G, Goldblatt, J, Hopper, J, Kirk, J, Leary, J, Lindeman, G, Niedermayr, E, Phillips, K, Picken, S, Pupo, G, Saunders, C, Scott, C, Spurdle, A, Suthers, G, Tucker, K, Chenevix-Trench, G, , K. Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast cancer research : BCR. 2006; 8:R12 [Abstract]

2005

  • Graham, J, Yager, M, Hill, H, Byth, K, O'Neill, G, Clarke, C. Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells. Molecular endocrinology ( Baltimore , Md. ). 2005; 19:2713-35 [Abstract]
  • Webster, L, Bilous, A, Willis, L, Byth, K, Burgemeister, F, Salisbury , E, Clarke, C, Balleine, R. Histopathologic indicators of breast cancer biology: insights from population mammographic screening. British journal of cancer. 2005; 92:1366-71 [Abstract]
  • Aghmesheh, M, Edwards, L, Clarke, C, Byth, K, Katzenellenbogen, B, Russell, P, Friedlander, M, Tucker, K, de Fazio, A. Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas. Gynecologic oncology. 2005; 97:16-25 [Abstract]
  • Wong, M, Evans, S, Rivory, L, Hoskins, J, Mann, G, Farlow, D, Clarke, C, Balleine, R, Gurney, H. Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Clinical pharmacology and therapeutics. 2005; 77:33-42 [Abstract]
  • van den Heuvel, M, Chantakru, S, Xuemei, X, Evans, S, Tekpetey, F, Mote, P, Clarke, C, Croy, B. Trafficking of circulating pro-NK cells to the decidualizing uterus: regulatory mechanisms in the mouse and human. Immunological investigations. 2005; 34:273-93 [Abstract]

2004

  • Gava, N, Clarke, C, Byth, K, Arnett-Mansfield, R, deFazio, A. Expression of progesterone receptors A and B in the mouse ovary during the estrous cycle. Endocrinology. 2004; 145:3487-94 [Abstract]
  • Wong, M, Balleine, R, Collins, M, Liddle, C, Clarke, C, Gurney, H. CYP3A5 genotype and midazolam clearance in Australian patients receiving chemotherapy. Clinical pharmacology and therapeutics. 2004; 75:529-38 [Abstract]
  • Balleine, R, Earls, P, Webster, L, Mote, P, deFazio, A, Harnett, P, Clarke, C. Expression of progesterone receptor A and B isoforms in low-grade endometrial stromal sarcoma. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2004; 23:138-44 [Abstract]
  • Arnett-Mansfield, R, DeFazio, A, Mote, P, Clarke, C. Subnuclear distribution of progesterone receptors A and B in normal and malignant endometrium. The Journal of clinical endocrinology and metabolism. 2004; 89:1429-42 [Abstract]
  • Mote, P, Leary, J, Avery, K, Sandelin, K, Chenevix-Trench, G, Kirk, J, Clarke, C, , K. Germ-line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen-responsive proteins and the predominance of progesterone receptor A. Genes, chromosomes & cancer. 2004; 39:236-48 [Abstract]
  • McGowan, E, Saad, S, Bendall, L, Bradstock, K, Clarke, C. Effect of progesterone receptor a predominance on breast cancer cell migration into bone marrow fibroblasts. Breast cancer research and treatment. 2004; 83:211-20 [Abstract]

2003

  • McGowan, E, Weinberger, R, Graham, J, Hill, H, Hughes, J, O'Neill, G, Clarke, C. Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels. Journal Of Molecular Endocrinology. 2003; 31:241-253

2002

  • Kennedy, C, Byth, K, Clarke, C, deFazio, A. Cell proliferation in the normal mouse mammary gland and inhibition by phenylbutyrate. Molecular Cancer Therapeutics. 2002; 12:1025-1033
  • Mote, P, Bartow, S, Tran, N, Clarke, C. Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis. Breast Cancer Research And Treatment. 2002; 72:163-172
  • Graham, J, Clarke, C. Progesterone receptors - animal models and cell signaling in breast cancer: expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Research. 2002; 4(5):187-190

2001

  • Mote, P, Johnston, J, Manninen, T, Tuohimaa, P, Clarke, C. Detection of progesterone receptor forms A and B by immunohistochemical analysis. Journal of Clinical Pathology. 2001; 38:733-745
  • Birrell, S, Tilley, W, Clarke, C, Birrell, S, Bruchovsky, N. Hormones and Cancer: new insights, new challenges. Trends In Endocrinology and Metabolism. 2001; 137:378-379
  • Arnett Mansfield, R, deFazio, A, Wain, G, Jaworski, R, Byth, K, Mote, P, Clarke, C. Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium1. Cancer Research. 2001; 10:182-189
  • Balleine, R, Humphrey, K, Clarke, C. Tumour banks: providing human tissue for cancer research. Medical Journal of Australia . 2001; 41:320-325

2000

  • Mote, P, Balleine, R, Mcgowan, E, Clarke, C. Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma. Human Reproduction. 2000; 15:48 -56
  • Davis, T, Kennedy, C, Chiew, Y, Clarke, C, de Fazio, A. Histone Deacetylase Inhibitors Decrease Proliferation and Modulate Cell Cycle Gene Expression in Normal Mammary Epithelial Cells. Clinical Cancer Research. 2000; 6:4334-4342
  • Balleine, R, Schoenberg Fejzo, M, Sathasivam, P, Basset, P, Clarke, C, Byrne, J. The hD52 (TDP52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma. Genes, Chromosomes & Cancer. 2000; 29:48-57

 

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Contact details

T +61 2 9845 9068
F +61 2 9845 9102
E Christine_clarke@wmi.usyd.edu.au

 

 

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