 Dr David Booth
Genetics of Multiple Sclerosis Research Group
Dr Booth is a research scientist studying the genetics of multiple sclerosis.
He gained his PhD from the Imperial College in London, and has since specialized in the genetics of amyloidosis, and of familial Mediterranean fever, prior to joining the IIAR to work on the genetics of multiple sclerosis in 2001.
Research Interests
David's overall goal is to use genetics to better characterise multiple sclerosis and so facilitate the design and use of drugs to treat the disease.
He and his team are using positional cloning strategies to identify genes associated with susceptibility to MS, investigating candidate genes for association with disease susceptibility and progression, and microarray analysis to identify molecular profiles for various MS disease states.
The molecular basis for the association of CD127 and other genes with MS
is being investigated.
His group is also studying neutralizing antibodies to the main treatment for MS, interferon beta, and providing a diagnostic service measuring this in Australasian MS patients. This work should help in developing a pharmacogenomic strategy for MS treatment.
Publications
- Booth DR, Arthur AT, Teutsch SM, Bye C, Rubio J, Armati PJ, Pollard JD, Heard RN, Stewart GJ; The Southern MS Genetics Consortium. Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. J Mol Med. 2005 Oct;83(10):822-30. [Abstract]
- McKay FC, Swain LI, Schibeci SD, Rubio JP, Kilpatrick TJ, Heard RN,
Stewart GJ, Booth DR. Haplotypes of the interleukin 7 receptor alpha
gene are correlated with altered expression in whole blood cells in
multiple sclerosis. Genes Immun. 2008 Jan;9(1):1-6. Epub 2007 Oct 11. [Abstract]
- Arthur AT, Armati PJ, Bye C, Southern MS Genetics Consortium, Heard RNS,
Stewart GJ, Pollard JD, Booth DR. Genes implicated in multiple
sclerosis pathogenesis from consilience of genotyping and expression
profiles in relapse and remission. BMC Medical Genetics. 2008 Mar 19;9:17. [Abstract]
- International Multiple Sclerosis Genetics Consortium (IMSGC, incl Booth
DR). Refining genetic associations in multiple sclerosis. Lancet Neurol. 2008 Jul;7(7):567-9. [Abstract]
- Gandhi K. McKay FC, Schibeci SD, Arthur J, Heard RN, Stewart GJ, Booth
DR. Baff is a biological Response Marker to Interferon beta. J Int Cyt
Res. 2008 Sep;28(9):529-39. [Abstract]
- De Jager P, et al (incl Booth DR, Arthur A, Stewart GJ) The role of the
CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009
Feb 23. [Abstract]
Contact details
T +61 2 98458498
F +61 2 98913889
E david_booth@wmi.usyd.edu.au
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